Lisinopril is an angiotensin-converting enzyme inhibitor. It has properties to lower blood pressure, corrects myocardial function, dilates blood vessels and removes sodium salts from the body.
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With prolonged use in patients, there is a decrease in hypertrophy of the walls of blood vessels and myocardium, and the process of blood circulation is getting better.
The drug improves the quality and life expectancy of patients with chronic heart disease, and also prevents the progression of ventricular dysfunction after myocardial infarction.
The drug in question belongs to the group of cardiovascular, is a white powder that is very difficult to dissolve in methanol, does not dissolve in ethanol, but can be used to prepare an aqueous solution.
Lisinopril acts “aimed” – expands the arteries, supports the myocardium in patients with diagnosed and progressive chronic heart failure, stabilizes the pressure in the arterial capillaries and normalizes blood flow to the myocardium after suffering or existing ischemic heart disease.
The drug in question begins to “work” within an hour after entering the body, the maximum concentration of the main active substance (and this is lisinopril) in the blood is determined on average after 5 hours (in the same period, the maximum effectiveness appears), and the duration of the drug is 24 hours.
Indications for use
Lisinopril is indicated for:
- Arterial hypertension (persistent increase in blood pressure), both in combination with other antihypertensive drugs, and as monotherapy;
- Chronic heart failure (with concurrent administration of digitalis drugs and diuretics);
- Acute myocardial infarction (in the postinfarction period, in a stable state).
- Age under 18;
- Hereditary idiopathic edema or angioedema of Quincke;
- History of angioedema, incl. as a result of the use of ACE inhibitors;
- Lactose intolerance, glucose-galactose malabsorption, lactase deficiency;
- Hypersensitivity to drug components or other ACE inhibitors.
Method of reception
The initial dose is 10 mg / day, the maintenance dose is 20 mg / day. The maximum daily dose is 40 mg. It may take 2-4 weeks to fully develop the effect, which should be taken into account when increasing the dose. If the use of the drug at the maximum dose does not cause a sufficient therapeutic effect, then an additional prescription of another antihypertensive drug is possible.
In patients who have previously received diuretics, it is necessary to cancel them 2-3 days before starting the use of the drug. If it is impossible to withdraw diuretics, the initial dose of lisinopril should be no more than 5 mg / day.
Renovascular hypertension or other conditions with increased activity of the renin-angiotensin-aldosterone system: the initial dose is 2.5-5 mg / day under the control of blood pressure, renal function, and serum potassium concentration. The maintenance dose is set depending on the value of blood pressure.